Abstract：The increase of the residual N-vinyl pyrrolidone (NVP) in the milling process of polyvinyl pyrrolidone (PVP) was studied. The PVP powder was treated by high temperature removal method and dynamic negative pressure removal method to remove the residual NVP. The treated PVP powder was analyzed by high performance liquid chromatography (HPLC), Ubbelohde viscometer, Laser diffraction particle size analyzers and powder performance tester. The results showed that the residual NVP in PVP powder was effectively removed by the dynamic negative pressure removal method, and the residual NVP was reduced from 13.30 mg/kg to 3.60 mg/kg after 3 h treated, which met the pharmacopoeia standard of residual NVP less than 10 mg/kg, while, the appearance, particle size and powder properties of PVP products had a negligible effect in this method.
SUN Xudong,ZHANG Senlin,ZHANG Junwei et al. Study of Residual Monomer for Polyvinylpyrrolidone in Milling Process and Removal[J]. Chemical Reaction Engineering and Technology, 2021, 37(4): 345-350.
