Analysis on Thiophene Ester Synthesis Process by Combination of Online Infrared and Calorimetry
1. Institute of Industry and Trade Measurement Technology, China Jiliang University, Hangzhou 310018, China;
2. Hangzhou Young instruments Company Limited, Hangzhou 310018, China;
3. Zhejiang Academy of Safety Science and Technology, Hangzhou 310012, China
Abstract：In order to clearly understand, evaluate the chemical reaction process, and determine the direction of reaction optimization, an in-situ detection system was developed to monitor the reaction in a batch reactor. In this method, the reaction calorimeter was used to accurately control and measured the process variables such as temperature, and the online infrared (IR) was used for continuous real-time detection of changes in the functional groups of the substance. The real-time exothermic heat flow, heat conversion and other thermodynamic information of the chemical reaction process, and the trend of the proportion of reactants and products in the sample over time could be obtained by this combination. By measuring and comparing of reaction data under different process conditions, the effects of process conditions on the reaction process and the final product are investigated. The method was applied to the thiophene ester synthesis process, and it was proved that adjusting the process temperature could improve the quality of the final product, and the thermal danger of the reaction could be controlled. The in-situ measurement and analysis method based on the combination of online IR and calorimetric technology could be applied to research and cognitive chemical reaction processes.
LUO Peng1,XU Qiyue1,YE Shuliang1 et al. Analysis on Thiophene Ester Synthesis Process by Combination of Online Infrared and Calorimetry[J]. 化学反应工程与工艺, 2020, 36(1): 74-81.
