Abstract： The synthesis of 3-chloro-2,2-dimethylpropyl ester of ibuprofen (ibuprofen chloroester) from the ketal by 1,2-aryl-transposition rearrangement is a key step in the production of ibuprofen. The effects of reaction temperature, catalyst concentration, catalyst′s feeding time and reaction time on the yield of ibuprofen chloroester were investigated by single factor experiments. The response surface methodology was used to optimize the synthesis process of ibuprofen chloroester. The optimum conditions of this process were determined as follows: reaction temperature 136 ℃, mass fraction of catalyst 4.0% and reaction time 1.7 h. The predicted value of ibuprofen chloroester yield was 97.78% under the optimum conditions and was basically in agreement with the experimental value(97.72%). The reason for catalyst deactivation was analyzed and verified. The results showed that the neopentyl glycol contained in the raw material liquid reacted with the catalyst, which resulted in the reduction of the activity of the catalyst and the decrease of the reaction rate.
Zhang Ping,Kong Lingqi,Zheng Shiqing et al. Optimization of Synthesis Process of 3-Chloro-2,2-Dimethylpropyl Ibuprofen Ester[J]. 化学反应工程与工艺, 2018, 34(3): 268-275.
