Abstract：A green preparation technology of 2-phosphonobutane-1,2,4-tricarboxylic acid pentamethyl ester to 2-phosphonobutane-1,2,4-tricarboxylic acid(PBTCA) with dry hydrogen chloride gas was studied．In a novel experimental apparatus with a glass stirred tank reactor for gas-liquid reaction, the acidolysis kinetics of 2-phosphonobutane-1,2,4-tricarboxylic acid pentamethyl ester and 2-phosphonobutane-1,2,4-tricarboxylic acid three methyl ester were determined at different temperatures. By consecutive first-order kinetics models, the apparent activation energies were 37.87 kJ/mol for 2-phosphonobutane-1,2,4-tricarboxylic acid pentamethyl ester acidolysis and 42.72 kJ/mol for 2-phosphonobutane-1,2,4-tricarboxylic acid three methyl ester acidolysis. The results showed that it was feasible to prepare PBTCA from acidolysis of 2-phosphonobutane- 1,2,4-tricarboxylic acid pentamethyl ester with hydrogen chloride.
