Synthesis of β-Amino Alcohol by Ring Opening Amination of Epoxybutane
SUN Yanrong, MA Liguo, ZHANG Zhipeng, LI Saisong, LI Dongzhi, SHEN Peng, LI Shuangwen
College of Materials Engineering, Hebei Provincial Key Laboratory of Thermal Protection Materials, North China Institute of Aerospace Engineering, Langfang 065000, China
Abstract For green and efficient synthesis of β-amino alcohol compounds, a β-amino alcohol with a large functional group was synthesized using epoxybutane and pentamine as raw materials and its structure was characterized in this paper. It was found that the β-amino alcohol could be efficiently synthesized by the reaction of epoxybutane and pentamine in deionized water solvent. The yield of the β-amino alcohol was about 87% when the molar ratio of epoxybutane to pentamine was 1:15 and the reaction was carried out at room temperature in a deionized water solvent system for 3 h. The ring opening aminolysis of epoxybutane to β-amino alcohol without catalyst was easy to operate and showed good product selectivity, which was an environmentally friendly preparation technology of β-amino alcohol belonging to the category of "green chemistry".
SUN Yanrong,MA Liguo,ZHANG Zhipeng et al. Synthesis of β-Amino Alcohol by Ring Opening Amination of Epoxybutane[J]. Chemical Reaction Engineering and Technology, 2023, 39(5): 470-474.
SUN Yanrong,MA Liguo,ZHANG Zhipeng et al. Synthesis of β-Amino Alcohol by Ring Opening Amination of Epoxybutane[J]. Chemical Reaction Engineering and Technology, 2023, 39(5): 470-474.
