Abstract：High-purity acetonitrile with high added value can be prepared from industrial-grade acetonitrile through impurity removal and purification. To develop a stable and efficient process for the production of high-purity acetonitrile, this study adopted a combined process consisting of oxidation, adsorption, and distillation. Using industrial-grade acetonitrile as the raw material, the effects of oxidant type, dosage, and reaction time; adsorbent type, dosage, and contact time; as well as distillation cut ratios (speed ratio) on product quality were investigated. The results showed that potassium permanganate was the optimal oxidant at a dosage of 0.25% (mass fraction) with a reaction time of 2 h; 5A molecular sieves were selected as the adsorbent with a contact time of 24 h and a mass ratio of 1?3; the distillation ratio of forecut, product, and tailcut was controlled at 1?7?2. Under these optimized conditions, the ultraviolet absorbance and water content of the obtained acetonitrile met the technical requirements of Chromatographic purity grade (HPLC-grade) acetonitrile and were comparable to those of commercially available HPLC-grade foreign products.
LUO Chengjingyan,PEI Yixia. Research on the Refining Process of Industrial Grade Acetonitrile to Chromatographic-Purity Acetonitrile[J]. Chemical Reaction Engineering and Technology, 2025, 41(4): 503-509.
