Preparation of Supramolecular Nanomedicine Based on Host-Guest Interaction Between Camptothecin and Cyclodextrin
CAO Chenhui1, SUN Changrui2, YAO Xikuang2
1. Anhui Sholon New Material Technology Company Limited, Chuzhou 239500, China;
2. School of Flexible Electronics (Future Technology), Nanjing Tech University, Nanjing 211800, China
Abstract：To improve the poor water solubility of camptothecin and prevent the significant reduction in its anti-cancer effects caused by ring-opening under physiological conditions, a self-assembled supramolecular nanomedicine based on the host-guest interaction of camptothecin and β-cyclodextrin was designed and prepared in this work, and the effects of different water addition rates and polymerization degree of camptothecin on the construction of self-assembled nanomedicine were explored. The results showed that polycamptothecin with polymerization degrees of 5, 10, and 20 was obtained by controlling the ratio of monomers and initiators. At the same time, β-cyclodextrin with azide group was designed and synthesized, and the cyclodextrin was grafted to the end of hyaluronic acid by efficient Click reaction. In the end, supramolecular nanomedicine was self-assembled by the host-guest interaction between camptothecin and cyclodextrin. The slow acceleration of water droplets is conducive to self-assembly to form dispersed and uniform particles. It provides some reference significance for the design of nanomedicine in the future.
CAO Chenhui,SUN Changrui,YAO Xikuang. Preparation of Supramolecular Nanomedicine Based on Host-Guest Interaction Between Camptothecin and Cyclodextrin[J]. Chemical Reaction Engineering and Technology, 2024, 40(4): 333-341.
