Abstract：Fed-batch operation was widely used in the fermentation industry because it could effectively improve the environment, prolong the reaction time and eliminate the inhibition of substrate and end-products. The optimal feed reference trajectory of penicillin fermentation process was analyzed and numerically presented, and the results showed that the bang-singular-bang control problem could be solved effectively by orthogonal collocation on finite elements, and when the control input took zero-order hold within the finite points, the optimized reference trajectory was easy to implement in practice. As far as the penicillin fermentation process described in this paper was concerned, when the optimization target was set as the concentration of the product/unloading substrate, a better penicillin yield could be obtained, and the product conversion rate could be effectively controlled, and the cost of subsequent product/raw material separation could be reduced. The optimization scheme proposed could be extended to general Fed-batch process to assist industrial process to establish optimal feeding strategy.
WU Ziqi,WU Sichen,ZHAI Chi. Dynamic Optimization of Penicillin Fed-batch Fermentation Process for Obtaining Discontinuous Operational Sets[J]. Chemical Reaction Engineering and Technology, 2023, 39(6): 501-510.
