Synthesis and Process Research of β-Asaronol by Catalytic Hydrogenation Combined with SFC
1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, Xi’an 710069, China;
2. Shaanxi Institute for Food and Drug Control, Xi’an 710065, China;
3. China;Jiangsu Hanbon Science and Technology Co Ltd. Huai’an 223200, China;
4. China; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials science, Northwest University, Xi’an 710127, China
Abstract The crude (Z)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-ol (β-asaronol) was synthesized from 3-(2,4,5-trimethoxyphenyl)prop-2-yn-1-ol by optimizing Lindlar catalytic hydrogenation, under the conditions of mass ratio of catalyst to reactants 0.2, methanol as solvent, reaction time 4 h and room temperature. Then high purity β-asaronol was obtained by SFC purification. The conversion of raw materials was more than 98%. After purified by supercritical fluid chromatography (SFC) method, β-asaronol was obtained in 74%-81% total yield with good purity (>99%). The synthesis and purification process is stable and reliable, which provides material support for further study on the biological activity of β-asaronol.
SUN Ying1,LI Bin1,FAN Peinan1 et al. Synthesis and Process Research of β-Asaronol by Catalytic Hydrogenation Combined with SFC[J]. 化学反应工程与工艺, 2020, 36(5): 428-435.
SUN Ying1,LI Bin1,FAN Peinan1 et al. Synthesis and Process Research of β-Asaronol by Catalytic Hydrogenation Combined with SFC[J]. 化学反应工程与工艺, 2020, 36(5): 428-435.
